Elon Musk says that OpenAI's pivot from a charity to a for-profit
business is wrong and sets a concerning precedent for other
philanthropic efforts
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TLDR 2026-04-29
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Get your copy [4] to learn how these teams are moving faster and
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📱
BIG TECH & STARTUPS
MUSK TESTIFIES HE'S SUING OPENAI TO STOP ALTMAN'S ‘LOOTING' (8
MINUTE READ) [5]
Elon Musk says that OpenAI's pivot from a charity to a for-profit
business is wrong and sets a concerning precedent for other
philanthropic efforts. He is suing OpenAI and its co-founders, seeking
the unwinding of the for-profit restructuring of OpenAI. Musk says he
felt that OpenAI's founders took advantage of his money, reputation,
and guidance to get the startup off the ground, only to abandon its public-focused principles and capitalize on the project for their own
benefit. OpenAI's attorneys say that the lawsuit is primarily an
attempt to undermine a top competitor to Musk's own AI company.
OPENAI BRINGS ITS MODELS TO AMAZON'S CLOUD AFTER ENDING EXCLUSIVITY
WITH MICROSOFT (3 MINUTE READ) [6]
OpenAI's models will be available via Amazon Web Services in the next
few weeks. AWS customers will be able to experiment with OpenAI's
models and its Codex agent through Amazon Bedrock. A new service
called Amazon Bedrock Managed Agents powered by OpenAI will enable
customers to construct sophisticated, customized agents with memory of
previous interactions.
🚀
SCIENCE & FUTURISTIC TECHNOLOGY
CURIOUS CASES OF FINANCIAL ENGINEERING IN BIOTECH (32 MINUTE READ)
[7]
Finance doesn't really make drug development easier. However, it does
make failure more survivable. Financialization is just the process of
making implicit economic relationships explicit and tradable. Having
more liquid markets for biotech risk is almost certainly better than
having fewer. The industry being willing to fund biology that's
expensive and likely to fail could result in more discoveries that
change the world.
ANTIBIOTICS ARE AN ECONOMIC FAILURE (17 MINUTE READ) [8]
The discovery of antibiotics enabled many of our modern medical
procedures, including many routine surgeries and immunosuppressant
treatments such as chemotherapy. Antibiotic resistance is considered
to be one of the greatest public health threats to humanity. If a new antibiotic entered the market, it would either be used as a last line
of defense, which means few doses would be sold, or it would be widely
used until resistance developed again, after which sales would drop. Antibiotics are only used for a few days, so there's little profit
potential. These factors mean there's less money in developing and
selling antibiotics compared to drugs for chronic diseases.
💻
PROGRAMMING, DESIGN & DATA SCIENCE
THE TRUST PROBLEM WITH AI AGENTS (SPONSOR) [9]
You've felt it: a file changed, a dependency added, and you didn't
ask for either. Opacity, scope creep, and no shared reasoning are
killing developer trust in AI agents. Join the waitlist [10] and
follow the 5-part series. [11]
LONG-RUNNING AGENTS (26 MINUTE READ) [12]
Long-running agents can keep making progress over time across many
context windows and sandboxes. They can recover from failure, leave
structural artifacts behind, and resume where they left off. This post
looks at the current state of long-running agents and explains how an
engineer can use long-running agents today without writing the whole
thing from scratch.
GITHUB ACTIONS IS THE WEAKEST LINK (14 MINUTE READ) [13]
Almost every open source supply chain incident from the past eighteen
months involves GitHub Actions features behaving exactly as
documented. Actions is basically a package manager with no lockfile,
no integrity hashes, and no transitive visibility. The whole product
is a collection of features that are convenient, but very easy to
assemble into something dangerous. GitHub plans to add fixes, but the
company says that changing the defaults will break existing workflows.
🎁
MISCELLANEOUS
SOFTWARE IS EATING THE WORLD (BUT ACTUALLY THIS TIME) (32 MINUTE
READ) [14]
Software ate distribution, but most of the work was still done by
humans. AI changes that - the work is now becoming software. Agents
can read, reason, call tools, verify, revise, and perform long-running
tasks. As models commoditize, the apps that capture messy operational
data will be the ones to improve fastest and defend their position
longest.
HOW CHATGPT SERVES ADS (5 MINUTE READ) [15]
OpenAI's ad platform has two halves. The ChatGPT back end injects
structured objects into the conversation while the model is
responding. On the merchant side, a tracking SDK runs in the visitor's
browser and reports product views back to OpenAI. These two parts are
tied together by Fernet-encrypted click tokens. This post explains
each part of the distribution loop in detail.
⚡
QUICK LINKS
THE TRUST PROBLEM WITH AI AGENTS (SPONSOR) [9]
You've felt it: changes you didn't request. Opacity, scope creep, and
missing reasoning erode trust in AI agents. This 5-part series
explores fixes — join the waitlist [10] and follow along today now.
[11]
BEFORE GITHUB (15 MINUTE READ) [16]
Open source was a much smaller world before GitHub, and projects had
to run their own infrastructure.
GHOSTTY IS LEAVING GITHUB (4 MINUTE READ) [17]
GitHub outages have gotten so common that they are negatively
impacting developers' ability to work.
WARP (GITHUB REPO) [18]
The new open-source Warp repository is funded by OpenAI, and the new
agentic management workflows are powered by GPT models.
BECOME A CURATOR FOR TLDR AI (3-5 HRS/WEEK) [19]
TLDR is looking for an engineer/researcher at a major AI lab or
startup to help write for 1M+ subscribers. Our curators have been
invited to Google I/O and OpenAI DevDay, scouted for Tier 1 VCs, and
get early access to unreleased TLDR products. Learn more [20].
AI REWARDS STRICT APIS (4 MINUTE READ) [21]
AI agents struggle with ambiguity, so strict APIs are an important
advantage.
A NEW TYPE OF NEUROPLASTICITY REWIRES THE BRAIN AFTER A SINGLE
EXPERIENCE (16 MINUTE READ) [22]
Behavioral timescale synaptic plasticity is a type of learning in the hippocampus that may help the brain learn in a single attempt.
ARE PREDICTION MARKETS GOOD FOR ANYTHING? (32 MINUTE READ) [23]
Despite their founders calling them 'truth machines', prediction
markets are overwhelmingly in service to their traders, not the
seekers of truth.
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